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Genetic drift, also known as random genetic drift, allelic drift or the Wright effect, [1] is the change in the frequency of an existing gene variant in a population due to random chance. [ 2 ] Genetic drift may cause gene variants to disappear completely and thereby reduce genetic variation . [ 3 ]
The genetic drift caused by a population bottleneck can change the proportional random distribution of alleles and even lead to loss of alleles. The chances of inbreeding and genetic homogeneity can increase, possibly leading to inbreeding depression. Smaller population size can also cause deleterious mutations to accumulate. [3]
Founder effect: The original population (left) could give rise to different founder populations (right). In population genetics, the founder effect is the loss of genetic variation that occurs when a new population is established by a very small number of individuals from a larger population.
Genetic divergence will always accompany reproductive isolation, either due to novel adaptations via selection and/or due to genetic drift, and is the principal mechanism underlying speciation. On a molecular genetics level, genetic divergence is due to changes in a small number of genes in a species, resulting in speciation . [ 2 ]
The expansion of humans from Africa affected the distribution of genetic variation in two other ways. First, smaller (founder) populations experience greater genetic drift because of increased fluctuations in neutral polymorphisms. Second, new polymorphisms that arose in one group were less likely to be transmitted to other groups as gene flow ...
Genetic variation is the difference in DNA among individuals [1] or the differences between populations among the same species. [2] The multiple sources of genetic variation include mutation and genetic recombination. [3] Mutations are the ultimate sources of genetic variation, but other mechanisms, such as genetic drift, contribute to it, as ...
[5] [6] [7] Alternatively, larger populations are affected less by genetic drift because drift is measured using the equation 1/2N, with "N" referring to population size; it takes longer for alleles to become fixed because "N" is higher. One example of large populations showing greater adaptive evolutionary ability is the red flour beetle.
A highly indicative test of changes in allele frequencies is the QTL sign test, and other tests include the Ka/Ks ratio test and the relative rate test. The QTL sign test compares the number of antagonistic QTL to a neutral model, and allows for testing of directional selection against genetic drift. [11]