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A 2011 Cochrane review found that, compared with other antidepressants, it is more likely to cause weight gain and sleepiness, but it is less likely to cause tremors than tricyclic antidepressants, and less likely to cause nausea and sexual dysfunction than selective serotonin reuptake inhibitors. [13]
As Americans are increasingly reaching for pharmaceutical solutions for depression—about one in eight U.S. adults takes antidepressants—scientists have been innovating novel treatments for it.
At the 1-year and 2-year marks compared to sertraline, bupropion’s estimations for weight gain were still lower. Escitalopram was still associated with weight gain after 1 year but not after 2 ...
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
Many common antidepressants can cause weight gain over time, but that's not a reason to avoid taking medication for mental health issues, experts say. - Joe Raedle/Getty Images/File
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