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Loop diuretics usually have a ceiling effect whereby doses greater than a certain maximum amount will not increase the clinical effect of the drug. Also, there is a threshold minimum concentration of loop diuretics that needs to be achieved at the thick ascending limb to enable the onset of abrupt diuresis.
Pages in category "Loop diuretics" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. ...
Diuretics are contraindicated in cases of severe electrolyte abnormalities and should not be administered until an electrolyte balance is restored. Special attention should be given to the use of thiazide and loop diuretics as they may exacerbate diabetes and gout. [4]
Loop diuretics (8 P) M. Mercurial ... Potassium-sparing diuretics (1 C, 8 P) T. Thiazides (15 P) Pages in category "Diuretics" ... This list may not reflect recent ...
Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys. [4] [2] Bumetanide was patented in 1968 and came into medical use in 1972. [5] It is on the World Health Organization's List of Essential Medicines. [6] It is available as a generic medication. [4]
Loop diuretics, including torsemide, may decrease total body thiamine, particularly in people with poor thiamine intake, and this depletion may worsen heart failure. It is therefore reasonable to either also give thiamine supplements or to check blood thiamine levels in those being treated with chronic loop diuretics.
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The thiazide drug class was discovered and developed at Merck and Co. in the 1950s. [3] The first approved drug of this class, chlorothiazide, was marketed under the trade name Diuril beginning in 1958. [3] In most countries, thiazides are the least expensive antihypertensive drugs available. [4]
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