Search results
Results from the WOW.Com Content Network
Osteopontin is minimally expressed under normal conditions, but accumulates quickly as heart function declines. [ 101 ] [ 102 ] Specifically, it plays a central role in the remodeling response to myocardial infarction , and is dramatically upregulated in hypertrophic (HCM) and dilated cardiomyopathy (DCM) . [ 102 ]
Examples of matricellular proteins include the CCN family of proteins (also known as CCN intercellular signaling protein), [5] fibulins, osteopontin, periostin, SPARC family members, tenascin(s), and thrombospondins. Many of these proteins have important functions in wound healing and tissue repair.
Osteonectin is a 40 kDa acidic and cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca 2+ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an EF hand motif at the carboxy terminus region (domain IV).
osteopontin (OPN) bone sialoprotein (BSP) dentin matrix protein 1 (DMP1) dentin sialophosphoprotein (DSPP) matrix extracellular phosphoglycoprotein (MEPE) The genes coding for members of the SIBLING protein family are similarly organized and are all located on human chromosome 4q21-23. [3]
They synthesize dense, crosslinked collagen and specialized proteins in much smaller quantities, including osteocalcin and osteopontin, which compose the organic matrix of bone. In organized groups of disconnected cells, osteoblasts produce hydroxyapatite , the bone mineral , that is deposited in a highly regulated manner, into the inorganic ...
104099 Ensembl ENSG00000144668 ENSMUSG00000039115 UniProt Q13797 B8JK39 RefSeq (mRNA) NM_002207 NM_001113514 NM_133721 RefSeq (protein) NP_002198 NP_001106986 NP_598482 Location (UCSC) Chr 3: 37.45 – 37.82 Mb Chr 9: 118.44 – 118.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22 ...
This gene codes for cathepsin K, a lysosomal cysteine protease that is highly expressed in osteoclasts and plays a significant role in bone remodelling by degenerating the bone matrix proteins such as type I collagen, osteopontin, and osteonectin. Defective function of cathepsin K therefore results in failure of normal degradation of the ...
Based on the molecular mechanisms of Osteopontin induction and function in cancer metastasis, he has established key paradigms. Osteopontin and variant CD44 interact, and this is essential for metastasis by several types of cancer. Multiple Osteopontin splice variants are present in malignant, but not in benign human breast (and other) tumor cells.