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The plant glutamate cysteine ligase is a redox-sensitive homodimeric enzyme, conserved in the plant kingdom. [26] In an oxidizing environment, intermolecular disulfide bridges are formed and the enzyme switches to the dimeric active state. The midpoint potential of the critical cysteine pair is -318 mV.
14629 Ensembl ENSG00000001084 ENSMUSG00000032350 UniProt P48506 P97494 RefSeq (mRNA) NM_001498 NM_001197115 NM_010295 RefSeq (protein) NP_001184044 NP_001489 NP_034425 Location (UCSC) Chr 6: 53.5 – 53.62 Mb Chr 9: 77.66 – 77.7 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutamate–cysteine ligase catalytic subunit is an enzyme that in humans is encoded by the GCLC gene ...
Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene. [5] [6] Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light
γ-L-Glutamyl-L-cysteine, also known as γ-glutamylcysteine (GGC), is a dipeptide found in animals, plants, fungi, some bacteria, and archaea. It has a relatively unusual γ-bond between the constituent amino acids , L -glutamic acid and L -cysteine and is a key intermediate in the γ-glutamyl cycle first described by Meister in the 1970s.
Glutamine synthetase (GS) (EC 6.3.1.2) [3] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate Glutamine synthetase catalyzed reaction
The systematic name of this enzyme class is gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming). Other names in common use include glutathione synthetase, and GSH synthetase. This enzyme participates in glutamate metabolism and glutathione metabolism. At least one compound, Phosphinate is known to inhibit this enzyme. [citation needed]
L-Cysteine consumption pathways; Enzyme ... glutamate–cysteine ligase [8] → γ-glutamyl cysteine/ADP and P i: ATP L-Cysteine is the product of several processes ...
First, γ-glutamylcysteine is synthesized from L-glutamate and L-cysteine. This conversion requires the enzyme glutamate–cysteine ligase (GCL, glutamate cysteine synthase). This reaction is the rate-limiting step in glutathione synthesis. [3] Second, glycine is added to the C-terminal of γ-glutamylcysteine.
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