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Metanx is a prescription medical food made by Alfasigma that contains L-methylfolate (as Metafolin, a calcium salt of vitamin B 9), methylcobalamin (vitamin B 12) and pyridoxal 5'-phosphate (vitamin B 6). It is a vitamin B supplement. Metanx is indicated for the dietary management of peripheral neuropathy (i.e. DPN). [1]
Vitamin B 6 Drug class Pyridoxal 5'-phosphate, the metabolically active form of vitamin B 6 Class identifiers Use Vitamin B 6 deficiency ATC code A11H Biological target enzyme cofactor Clinical data Drugs.com International Drug Names External links MeSH D025101 Legal status In Wikidata Vitamin B 6 is one of the B vitamins, and is an essential nutrient for humans. The term essential nutrient ...
Pyridoxine (PN) [4] is a form of vitamin B 6 found commonly in food and used as a dietary supplement.As a supplement it is used to treat and prevent pyridoxine deficiency, sideroblastic anaemia, pyridoxine-dependent epilepsy, certain metabolic disorders, side effects or complications of isoniazid use, and certain types of mushroom poisoning. [5]
Pyridoxamine was marketed as a dietary supplement, often as the hydrochloride salt, pyridoxamine dihydrochloride.However, in the United States, the FDA ruled in January 2009 that pyridoxamine must be regulated as a pharmaceutical drug because it is the active ingredient in Pyridorin, a drug designed by Biostratum, Inc., to prevent the progression of diabetic nephropathy.
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B 6, is a coenzyme in a variety of enzymatic reactions. The International Union of Biochemistry and Molecular Biology has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. [ 5 ]
Pyridoxine is converted to pyridoxal phosphate via two enzymes, pyridoxal kinase and pyridoxine 5′-phosphate oxidase. High levels of pyridoxine can inhibit these enzymes. As pyridoxal phosphate is the active form of vitamin B 6, this saturation of pyridoxine could mimic a deficiency of vitamin B 6. [23] [27]
Pyridoxine 5′-phosphate oxidase is an enzyme, encoded by the PNPO gene, [1] [2] [3] that catalyzes several reactions in the vitamin B 6 metabolism pathway. Pyridoxine 5′-phosphate oxidase catalyzes the final, rate-limiting step in vitamin B 6 metabolism, the biosynthesis of pyridoxal 5′-phosphate, the biologically active form of vitamin B 6 which acts as an essential cofactor. [4]
There are at least six naturally occurring vitamers of vitamin B 6 including pyridoxine, pyridoxal, and pyridoxamine as well as a 5'-phosphate derivative of each. All six naturally occurring vitamers of vitamin B 6 are found in foods. [3] Pyridoxine, along with its phosphorylated form, pyridoxine-5'-phosphate, are primarily found in plant-based ...
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