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Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. It increases in states of low bone density, such as osteoporosis , [ 1 ] [ 2 ] anorexia nervosa / caloric restriction , [ 3 ] [ 4 ] skeletal unweighting such as that which occurs in space travel , [ 5 ] [ 6 ] and ...
As ADSCs adhere to bone marrow endothelium, MSCs express several different molecules that increase the adhesion such as CD44 isoforms and integrins. As ADSCs transmigrate through vessels in bone marrow, interaction and signaling between stromal-derived chemokine factor -1 ( SDF-1 ) and receptor CXCR4 is the most crucial process.
Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. [2] Diet restrictions do not help prevent the buildup of lipids in the tissues because the cells in the tissues synthesize lipids from any precursor readily available (such as amino acids or carbohydrates). [1]
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).
However, he questioned if it was a rare genetic condition called Gaucher disease, which involves a buildup of fatty cells in the liver, spleen, and occasionally the bone marrow. (This happens ...
Marrow adipocytes are unilocular like white fat cells. The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in the setting of obesity. [4]
In mesenchymal stem cell therapy, most of the cells are extracted from the adult patient's bone marrow [2] [3] Mesenchymal stem cells can be obtained via a procedure called bone marrow aspiration. A needle is inserted into the back of the patients hip bone and cells are removed to be grown under controlled in vitro conditions in a lab. Over a ...
Bone marrow is a semi-solid tissue found within the spongy ... When "yellow" fatty marrow becomes replaced by tissue with more cellular composition, this change is ...
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