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Typhoid vaccines are vaccines that prevent typhoid fever. [1] [2] [3] Several types are widely available: typhoid conjugate vaccine (TCV), Ty21a (a live oral vaccine) and Vi capsular polysaccharide vaccine (ViPS) (an injectable subunit vaccine). They are about 30 to 70% effective in the first two years, depending on the specific vaccine in ...
Ty21a is a live attenuated bacterial vaccine that protects against typhoid.First licensed in Europe in 1983 and in the United States in 1989, it is an orally administered, live-attenuated Ty2 strain of S. Typhi in which multiple genes, including the genes responsible for the production of Vi, have been deleted so as to render it harmless but nevertheless immunogenic.
Although vaccination programs for typhoid have proven effective, they alone cannot eliminate typhoid fever. [39] Combining vaccines with public health efforts is the only proven way to control this disease. [39] Since the 1990s, the WHO has recommended two typhoid fever vaccines. The ViPS vaccine is given by injection and the Ty21a by capsules.
The Vi capsular polysaccharide vaccine (or ViCPS) is a typhoid vaccine recommended by the World Health Organization for the prevention of typhoid (another is Ty21a).The vaccine was first licensed in the US in 1994 and is made from the purified Vi capsular polysaccharide from the Ty2 Salmonella Typhi strain; it is a subunit vaccine.
The name comes from the Greek tûphos (τῦφος), meaning 'hazy' or 'smoky' and commonly used as a word for delusion, describing the state of mind of those infected. [7] While typhoid means 'typhus-like', typhus and typhoid fever are distinct diseases caused by different types of bacteria, the latter by specific strains of Salmonella typhi. [8]
Typhoid fever causes 11 million infections and more than 100,000 deaths per year, and is most prevalent in south Asia – which accounts for 70% of the global disease burden.
This discovery is now used to strengthen vaccines against typhoid fever, whooping cough, E. coli bacteria, Clostridioides difficile and anthrax. The conjugate vaccine for Hib produced high antibody levels, well above what was needed for protection, among infants from injections starting at age 2 months and persisting for years beyond.
Brigadier General Frederick Fuller Russell (1870 in Auburn, New York, USA – December 29, 1960) was a U.S. Army physician who perfected a typhoid vaccine in 1909. In 1911, a typhoid vaccination program was carried out to have the entire U.S. Army immunized. As a direct result of his research, the U.S. Army was the first military to make ...