Ad
related to: history of thalassemia disease pdf download book- Resources
Explore resources for HCPs.
See study results & more.
- Sign Up
Stay up to date. Sign up to receive
the latest thalassemia information.
- Emerging NTD Data
See how hemoglobin levels
affect NTD patients.
- Management
Find the latest thalassemia
management guidelines.
- Resources
Search results
Results from the WOW.Com Content Network
β thalassemia major (Mediterranean anemia or Cooley anemia) is caused by a β o /β o genotype. No functional β chains are produced, and thus no hemoglobin A can be assembled. This is the most severe form of β-thalassemia. β thalassemia intermedia is caused by a β + /β o or β + /β + genotype. In this form, some hemoglobin A is produced.
Family history and ancestry are factors that increase the risk of beta thalassemia. Depending on family history, if a person's parents or grandparents had beta thalassemia major or intermedia, there is a 75% (3 out of 4) probability (see inheritance chart at top of page) of the mutated gene being inherited by an offspring.
Hemoglobinopathy is the medical term for a group of inherited blood disorders involving the hemoglobin, the protein of red blood cells. [1] They are generally single-gene disorders and, in most cases, they are inherited as autosomal recessive traits.
Sickle cell-beta thalassemia is an inherited blood disorder. The disease may range in severity from being relatively benign and like sickle cell trait to being similar to sickle cell disease . [ 1 ] [ 2 ]
Cooley was born in Ann Arbor, Michigan, the son of Thomas McIntyre Cooley, a noted legal scholar.While Cooley was a boy, his father served variously as a professor and dean of the University of Michigan Law School, an Associate Justice and Chief Justice of the Michigan Supreme Court, and as the first chairman of the Interstate Commerce Commission. [1]
Hematologic diseases are disorders which primarily affect the blood and blood-forming organs. Hematologic diseases include rare genetic disorders, anemia , HIV , sickle cell disease and complications from chemotherapy or transfusions.
Hemoglobin H disease, also called alpha-thalassemia intermedia, is a disease affecting hemoglobin, the oxygen carrying molecule within red blood cells. It is a form of Alpha-thalassemia which most commonly occurs due to deletion of 3 out of 4 of the α-globin genes.
Kan and his collaborators found the deletion of a gene was the cause of alpha-thalassemia, [37] the first demonstration of its kind for any disease. [15] He was also the first to establish that a single DNA mutation could lead to a human disease, and the first to diagnose a human disease using DNA. [38]
Ad
related to: history of thalassemia disease pdf download book