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Mycobacterium tuberculosis (M. tb), also known as Koch's bacillus, is a species of pathogenic bacteria in the family Mycobacteriaceae and the causative agent of tuberculosis. [ 1 ] [ 2 ] First discovered in 1882 by Robert Koch , M. tuberculosis has an unusual, waxy coating on its cell surface primarily due to the presence of mycolic acid .
The primary site of infection in the lungs, known as the Ghon focus, is generally located in either the upper part of the lower lobe, or the lower part of the upper lobe. [13] Tuberculosis of the lungs may also occur via infection from the blood stream. This is known as a Simon focus and is typically found in the top of the lung. [91]
Infections associated with diseases are those infections that are associated with possible infectious etiologies that meet the requirements of Koch's postulates. Other methods of causation are described by the Bradford Hill criteria and evidence-based medicine .
Koch's postulates (/ k ɒ x / KOKH) [2] are four criteria designed to establish a causal relationship between a microbe and a disease. The postulates were formulated by Robert Koch and Friedrich Loeffler in 1884, based on earlier concepts described by Jakob Henle , and the statements were refined and published by Koch in 1890. [ 3 ]
Furthermore, although many different therapeutic options exist, especially with regards to non-tuberculosis mycobacterial infections – incision and drainage, aspiration biopsy and chemotherapy have all been proven to result in a complete cure of NTM-type infections – different treatments can cause different side-effects, including facial ...
Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the human body and by the tiny size of the lesions (1–5 mm). Its name comes from a distinctive pattern seen on a chest radiograph of many tiny spots distributed throughout the lung fields with the appearance similar to millet seeds—thus the term "miliary" tuberculosis.
“In adults over the age of 65, symptoms almost always include a cough, whereas with the flu, coughing is usually just present in about two-thirds of patients,” he says.
Persons with these findings, if they have a positive tuberculin skin test reaction, should be considered high-priority candidates for treatment of latent infection regardless of age. Conversely, calcified nodular lesions (calcified granuloma ) pose a very low risk for future progression to active tuberculosis.