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Calciphylaxis, also known as calcific uremic arteriolopathy (CUA) or “Grey Scale”, is a rare syndrome characterized by painful skin lesions.The pathogenesis of calciphylaxis is unclear but believed to involve calcification of the small blood vessels located within the fatty tissue and deeper layers of the skin, blood clots, and eventual death of skin cells due to lack of blood flow. [1]
Familial hypocalciuric hypercalcemia (FHH) is an inherited condition that can cause hypercalcemia, a serum calcium level typically above 10.2 mg/dL; although uncommon. [1] It is also known as familial benign hypocalciuric hypercalcemia (FBHH) where there is usually a family history of hypercalcemia which is mild, a urine calcium to creatinine ratio <0.01, and urine calcium <200 mg/day ...
Calcinosis cutis is an uncommon condition marked by calcium buildup in the skin and subcutaneous tissues. Calcinosis cutis can range in intensity from little nodules in one area of the body to huge, crippling lesions affecting a vast portion of the body. [1]
Diagnosis of this rare disease is often misdiagnosed or delayed, leading to results such as amputation and death. In a rare case, an 80 year old woman displayed symptoms resembling temporal arteritis. However, pathological findings confirmed that it was Mönckeberg's arteriosclerosis instead.
The branching may only be seen at the edge of one or two lesions but is still the clue to this diagnosis and a potentially serious underlying condition. [2] Inflammatory retiform purpura consists of redness around the lesion with associated central necrosis caused by vasculitic or infectious processes.
I've seen enough of this disease to know that if I had this diagnosis and were on dialysis, I would stop the dialysis. Bruce MacDonald Social Worker (9years) Hemodialysis Unit Royal Columbian Hospital New Westminster, BC Canada —Preceding unsigned comment added by 209.53.175.249 ( talk ) 16:24, 25 August 2010 (UTC) [ reply ]
If the underlying cause of the hypocalcemia can be addressed, the hyperparathyroidism will resolve. In people with chronic kidney failure, treatment consists of dietary restriction of phosphorus; supplements containing an active form of vitamin D, such as calcitriol, doxercalciferol, paricalcitol; and phosphate binders, which are either calcium-based and non-calcium based.
An extreme consequence is the occurrence of the rare condition named calciphylaxis. [ 33 ] Changes in mineral and bone metabolism that may cause 1) abnormalities of calcium , phosphorus ( phosphate ), parathyroid hormone , or vitamin D metabolism; 2) abnormalities in bone turnover , mineralization , volume, linear growth, or strength ( kidney ...