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Researchers have identified over 85 drugs with which grapefruit reacts adversely. [ 45 ] [ 1 ] According to a review done by the Canadian Medical Association , [ 1 ] there is an increase in the number of potential drugs that can interact with grapefruit juice, and of the number of fruit types that can interact with those drugs.
Blood pressure drugs aren't the only commonly prescribed medications that grapefruit juice can mess with — they also include anticoagulants that help prevent blood clots, organ-transplant ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds:
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Grapefruit juice can increase the serum concentrations of tadalafil and other medications in your body, which can lead to overdose-like results. Stick with water — it’s good for you.
Beyond adverse effects from the herb itself, "adulteration, inappropriate formulation, or lack of understanding of plant and drug interactions have led to adverse reactions that are sometimes life threatening or lethal." [3]
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health.
Research findings have demonstrated that grapefruit produced a clinically relevant interaction with more than 40 medications. Formal product information for a number of highly prescribed or essential medications now warn about the risk of a grapefruit-induced adverse drug interaction.