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The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [10] It is available as a generic medication. [5] [11] In 2022, it was the sixteenth most commonly prescribed medication in the United States, with more than 30 million prescriptions.
In short-term, acute situations, labetalol decreases blood pressure by decreasing systemic vascular resistance with little effect on stroke volume, heart rate and cardiac output. [23] During long-term use, labetalol can reduce heart rate during exercise while maintaining cardiac output by an increase in stroke volume .
Slowing down the conduction of electrical activity within the heart, by blocking the calcium channel during the plateau phase of the action potential of the heart (see: cardiac action potential), results in a negative chronotropic effect, or a lowering of heart rate. This can increase the potential for heart block.
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein.The intravenous route of administration is commonly used for rehydration or to provide nutrients for those who cannot, or will not—due to reduced mental states or otherwise—consume food or water by mouth.
Crank: High Voltage (alternately titled Crank 2: High Voltage) is a 2009 American action film directed by Neveldine/Taylor, and stars Jason Statham, Amy Smart, Clifton Collins Jr., Efren Ramirez, Bai Ling, David Carradine and Dwight Yoakam.
The M 2 muscarinic receptors are located in the heart and lungs. In the heart, they act to slow the heart rate down below the normal baseline sinus rhythm, by slowing the speed of depolarization. In humans, under resting conditions, vagal activity dominates over sympathetic activity.
The G-protein also activates a potassium channel GIRK-1 and GIRK-4, which allows K + to flow out of the cell, making the membrane potential more negative and slowing the pacemaker potential, therefore decreasing the rate of action potential production and therefore decreasing heart rate. [20] A decrease in heart rate is known as negative ...
It consists of a brief speed-up in heart rate, followed by a slow decrease back to the baseline rate. PVCs can occur naturally in most otherwise-healthy adults, so measuring the characteristics of a given person's HRT can offer a non-invasive way to evaluate certain aspects of their cardiac or autonomic function without applying artificial ...