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This leads to fluid-induced swelling of the extremities known as edema, build-up of fluid in the abdomen known as ascites, and fluid surrounding internal organs known as effusions. Patients also present with nonspecific findings such as fatigue and excessive weakness. Muehrcke's lines are a strong indicator of hypoalbuminemia. [2]
Gastric antral vascular ectasia (GAVE) is an uncommon cause of chronic gastrointestinal bleeding or iron deficiency anemia. [ 1 ] [ 2 ] The condition is associated with dilated small blood vessels in the gastric antrum , which is a distal part of the stomach . [ 1 ]
General causes of hypervolemia include excessive sodium or fluid intake, sodium or water retention and fluid shift into the intravascular space. [ 52 ] From the sixth week of pregnancy, hormonal changes cause an increase in the mother's blood volume due to an increase in plasma.
Regardless of the cause, sequestration of fluid within the abdomen leads to additional fluid retention by the kidneys due to stimulatory effect on blood pressure hormones, notably aldosterone. The sympathetic nervous system is also activated, and renin production is increased due to decreased perfusion of the kidney.
Fluid retention can be a symptom of underlying conditions such as kidney disease, heart failure and liver disease, says Badgett. Certain cancers and cancer treatments can cause edema.
Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide. [14] Pernicious anemia due to autoimmune problems occurs in about one per 1000 people in the US. Among those over the age of 60, about 2% have the condition. [8] It more commonly affects people of northern European descent. [2]
Treatment depends on the type and cause of the hemolytic anemia. [2] Symptoms of hemolytic anemia are similar to other forms of anemia (fatigue and shortness of breath), but in addition, the breakdown of red cells leads to jaundice and increases the risk of particular long-term complications, such as gallstones [4] and pulmonary hypertension. [5]
Before iron deficiency anemia sets in, “the body will do everything it can to retain the right number of red blood cells. So, it will deplete the storage iron before it depletes the red blood ...