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eBioMedicine is a peer-reviewed open access medical journal initially launched by Elsevier, shortly thereafter supported by Cell Press and The Lancet, and in 2018 incorporated in The Lancet family journals, at the occasion of the inception of its sister journal eClinicalMedicine (Impact Factor 17.033), also published by The Lancet. [1]
The enlarged cells that are able to re-enter the cell cycle are prone to DNA damage and experience abnormalities in signaling for repair (NHEJ pathway), eventually leading to a replication failure and a permanent cell-cycle exit. [24] Overall, a consistent correlation between larger cell size and senescence has been established.
Hedgehog is not free to move very far from the cells that make it and so it only activates a thin stripe of cells adjacent to the engrailed-expressing cells. When acting in this local fashion, hedgehog works as a paracrine factor. Only cells to one side of the engrailed-expressing cells are competent to respond to Hedgehog following interaction ...
In the absence of hypoxic conditions (i.e. physiological levels of oxygen), cancer cells preferentially convert glucose to lactate, according to Otto H. Warburg, who believed that aerobic glycolysis was the key metabolic change in cancer cell malignancy.
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction.Mitochondria are the organelles that generate energy for the cell and are found in every cell of the human body except red blood cells.
Those that are in CNS but not in blood suggest a diagnosis of MS. MRZ-Reaction: A polyspecific antiviral immune response against the viruses of measles, rubella and zoster found in 1992. [1] In some reports the MRZR showed a lower sensitivity than OCB (70% vs. 100%), but a higher specificity (69% vs. 92%) for MS. [1] free light chains (FLC ...
In some cases the exaggeration, possibly, is not intentional but occurs due to errors in translation between languages and synchronization of chronological systems. The species limit of human life is estimated by scientists at 125–127 years, [5] [6] and even in the most ideal conditions a person will not live longer due to aging of the body.
MELAS is a condition that affects many of the body's systems, particularly the brain and nervous system (encephalo-) and muscles (myopathy). In most cases, the signs and symptoms of this disorder appear in childhood following a period of normal development. [4]