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  2. Pyruvate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase

    Pyruvate dehydrogenase (PDH) deficiency is a congenital degenerative metabolic disease resulting from a mutation of the pyruvate dehydrogenase complex (PDC) located on the X chromosome. While defects have been identified in all 3 enzymes of the complex, the E1-α subunit is predominantly the culprit.

  3. Pyruvate dehydrogenase complex - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex

    Pyruvate dehydrogenase complex. Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric ...

  4. Pyruvate dehydrogenase (lipoamide) beta - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(l...

    Pyruvate dehydrogenase deficiency is characterized by the buildup of a chemical called lactic acid in the body and a variety of neurological problems. Signs and symptoms of this condition usually first appear shortly after birth, and they can vary widely among affected individuals.

  5. Pyruvate dehydrogenase (lipoamide) alpha 1 - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(l...

    Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial is an enzyme that in humans is encoded by the PDHA1 gene.The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA.

  6. Dihydrolipoyl transacetylase - Wikipedia

    en.wikipedia.org/wiki/Dihydrolipoyl_transacetylase

    Pyruvate decarboxylation requires a few cofactors in addition to the enzymes that make up the complex. The first is thiamine pyrophosphate (TPP), which is used by pyruvate dehydrogenase to oxidize pyruvate and to form a hydroxyethyl-TPP intermediate. This intermediate is taken up by dihydrolipoyl transacetylase and reacted with a second ...

  7. Pyruvate dehydrogenase kinase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_kinase

    The complex acts to convert pyruvate (a product of glycolysis in the cytosol) to acetyl-coA, which is then oxidized in the mitochondria to produce energy, in the citric acid cycle. By downregulating the activity of this complex, PDK will decrease the oxidation of pyruvate in mitochondria and increase the conversion of pyruvate to lactate in the ...

  8. File:Pyruvat.svg - Wikipedia

    en.wikipedia.org/wiki/File:Pyruvat.svg

    The following 36 pages use this file: 1,3-Bisphosphoglyceric acid; 2-Phosphoglyceric acid; 3-Phosphoglyceric acid; Acetyl-CoA; Aldolase A; Dihydrolipoamide dehydrogenase

  9. Pyruvate dehydrogenase (lipoamide) alpha 2 - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_(l...

    n/a Ensembl ENSG00000163114 n/a UniProt P29803 n/a RefSeq (mRNA) NM_005390 n/a RefSeq (protein) NP_005381 n/a Location (UCSC) Chr 4: 95.84 – 95.84 Mb n/a PubMed search n/a Wikidata View/Edit Human Pyruvate dehydrogenase (lipoamide) alpha 2, also known as pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial or PDHE1-A type II, is an enzyme that in humans is ...