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Pyruvate dehydrogenase is an enzyme that catalyzes the reaction of pyruvate and a lipoamide to give the acetylated dihydrolipoamide and carbon dioxide. The conversion requires the coenzyme thiamine pyrophosphate. Pyruvate dehydrogenase is usually encountered as a component, referred to as E1, of the pyruvate dehydrogenase complex (PDC). PDC ...
Pyruvate dehydrogenase deficiency is characterized by the buildup of a chemical called lactic acid in the body and a variety of neurological problems. Signs and symptoms of this condition usually first appear shortly after birth, and they can vary widely among affected individuals.
Pyruvate dehydrogenase complex. Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric ...
n/a Ensembl ENSG00000163114 n/a UniProt P29803 n/a RefSeq (mRNA) NM_005390 n/a RefSeq (protein) NP_005381 n/a Location (UCSC) Chr 4: 95.84 – 95.84 Mb n/a PubMed search n/a Wikidata View/Edit Human Pyruvate dehydrogenase (lipoamide) alpha 2, also known as pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial or PDHE1-A type II, is an enzyme that in humans is ...
The complex acts to convert pyruvate (a product of glycolysis in the cytosol) to acetyl-coA, which is then oxidized in the mitochondria to produce energy, in the citric acid cycle. By downregulating the activity of this complex, PDK will decrease the oxidation of pyruvate in mitochondria and increase the conversion of pyruvate to lactate in the ...
X-ray structures of PEPCK provide insight into the structure and the mechanism of PEPCK enzymatic activity. The mitochondrial isoform of chicken liver PEPCK complexed with Mn 2+ , Mn 2+ - phosphoenolpyruvate (PEP), and Mn 2+ -GDP provides information about its structure and how this enzyme catalyzes reactions. [ 10 ]
In Pyrococcus furiosus, the pyruvate, water dikinase enzyme has a subunit molecular mass of 92 kDa, and each subunit contains one calcium and one phosphorus atom. [1] This enzyme has a octomeric structure, meaning that pyruvate, water dikinase in Pyrococcus furiosus is an oligomer protein consisting of eight subunits in its quaternary structure ...
In enzymology, a pyruvate dehydrogenase (cytochrome) (EC 1.2.2.2) is an enzyme that catalyzes the chemical reaction pyruvate + ferricytochrome b 1 + H 2 O ⇌ {\displaystyle \rightleftharpoons } acetate + CO 2 + ferrocytochrome b 1