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Pitolisant is indicated in adults for the treatment of narcolepsy. [3] [4] Narcolepsy is a chronic sleep disorder that causes overwhelming daytime drowsiness. [4] Pitolisant is also indicated to improve alertness and reduce excessive daytime sleepiness in adults with obstructive sleep apnea. [5] [12]
Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Sodium oxybate, sold under the brand name Xyrem among others, is a medication used to treat symptoms of narcolepsy: sudden muscle weakness and excessive daytime sleepiness. [3] [8] [9] It is used sometimes in France and Italy as an anesthetic given intravenously.
Solriamfetol is used to promote wakefulness in the treatment of excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea in adults. [1] It appears to be more effective in improving excessive daytime sleepiness associated with obstructive sleep apnea than certain other wakefulness-promoting agents including modafinil, armodafinil, and pitolisant.
Pitolisant has been shown to be effective and well-tolerated for the treatment of narcolepsy with or without cataplexy. [182] [181] [180] Pitolisant is the only non-controlled anti-narcoleptic drug in the US. [180] It has shown minimal abuse risk in studies. [180] [183]
Experts say cataplexy, which is a loss of muscle tone, often accompanies narcolepsy. In the video, Sarah was working on a traditional Japanese dance to send to a choreographer friend ...
Cataplexy without narcolepsy is rare and the cause is unknown. The term cataplexy originates from the Greek κατά ( kata , meaning "down"), and πλῆξις ( plēxis , meaning "strike") [ 4 ] and it was first used around 1880 in German physiology literature to describe the phenomenon of tonic immobility also known as " playing possum " (in ...
Sorting out prescriptions and device replacement without the documents you’d typically have on hand may take longer. “The last thing we want is for people to end up in the emergency ...