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Commonly used tocolytic medications include β 2 agonists, calcium channel blockers, NSAIDs, and magnesium sulfate. These can assist in delaying preterm delivery by suppressing uterine muscle contractions and their use is intended to reduce fetal morbidity and mortality associated with preterm birth. [2]
Atosiban, sold under the brand name Tractocile among others, is an inhibitor of the hormones oxytocin and vasopressin.It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor.
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Isoxsuprine is used in humans for treatment of premature labor, i.e. a tocolytic, [6] and as a vasodilator for the treatment of cerebral vascular insufficiency, Raynaud's phenomenon, and other conditions. [7] Isoxsuprine may increase the heart rate, cause changes in blood pressure, and irritate the GI tract.
Hexoprenaline is a selective β 2 adrenergic receptor agonist used in the treatment of asthma. [2] Hexoprenaline is also used in some countries (such as Russia and Switzerland) as a tocolytic agent (i.e., labor suppressant), with the most common trade name being Gynipral.
The tocolytic agent atosiban (Tractocile) acts as an antagonist of oxytocin receptors. It is registered in many countries for use in suppressing premature labor between 24 and 33 weeks of gestation. It is registered in many countries for use in suppressing premature labor between 24 and 33 weeks of gestation.
Ritodrine, sold under the brand name Yutopar, is a tocolytic drug used to stop premature labor. [2] [3] This drug has been removed from the US market, according to FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt. The drug acts as a selective β 2-adrenergic receptor agonist. [4]
Magnesium sulfate was once used as a tocolytic, [27] [28] but meta-analyses have failed to support it as an anti-contraction medication. [29] [30] Usage for prolonged periods (more than five to seven days) may result in health problems for the baby. [31]