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Factors considered before deciding on whether warfarin or a DOAC or which direct factor Xa inhibitor is used, include: the presence or absence of valvular heart disease, state of kidney function, the risk of stroke and the risk of bleeding. [8]
In October 2010 the US FDA approved dabigatran etexilate for the prevention of stroke in patients with atrial fibrillation (AF). [6] [10] Many pharmaceutical companies have attempted to develop orally bioavailable DTI drugs but dabigatran etexilate is the only one to reach the market. [9]
Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant used to treat and prevent blood clots and to prevent stroke in people with atrial fibrillation. [ 6 ] [ 7 ] Specifically it is used to prevent blood clots following hip or knee replacement and in those with a history of prior clots. [ 6 ]
The Big Muddy River Correctional Center is a medium-security state prison for men located in Ina, Jefferson County, Illinois, owned and operated by the Illinois Department of Corrections. [ 1 ] The facility was first opened in 1993, and has a working capacity of 1958.
In May 2021, the Illinois Department of Corrections called for Stateville to be converted from a Level 1 maximum security facility to a multi-level facility focused on returning inmates to society. In March 2024, the State announced plans to temporarily close the prison, demolish it, and construct a new facility on the grounds. [11]
The IDOC is led by a director appointed by the Governor of Illinois, [3] and its headquarters are in Springfield. [4] The IDOC was established in 1970, combining the state's prisons, juvenile centers, and parole services. The juvenile corrections system was split off into the Illinois Department of Juvenile Justice on July 1, 2006. [3]
The Shawnee Correctional Center is a medium-security state prison for men located in Vienna, Johnson County, Illinois, owned and operated by the Illinois Department of Corrections. [1] The facility was first opened in 1984, and has a working capacity of 2147. The facility is adjacent to the state's Vienna Correctional Center.
Idarucizumab is a non-competitive inhibitor that forms complexes with dabigatran to counteract its anticoagulant effect within minutes of administration. [8] It binds to dabigatran that is free or bound to thrombin, as well as dabigatran's active metabolites. [9]