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Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. [1] Other symptoms may include excess sleepiness or poor feeding. [1] Complications may include seizures, cerebral palsy, or kernicterus. [1] In most of cases there is no specific underlying physiologic disorder. [2]
If neonatal cholestasis is suspected or an infant is presenting with jaundice after two weeks of life, total and conjugated bilirubin must be measured. [10] Neonatal cholestasis is present if conjugated bilirubin value is >20% of total serum bilirubin or if serum conjugated bilirubin concentration is greater than 1.0 mg/dL. [2]
In one study, tin mesoporphyrin was administered intramuscularly to a newborn that was only 46 hours old with a low birth weight who had also suffered from severe hyperbilirubinemia. [9] Along with blue light treatment, the newborn showed a steady decrease in its total serum biliverdin within 10 hours after administration. [10]
Newborn infant with Rhesus disease, a type of hemolytic disease of the newborn, suffering from hydrops fetalis (edema caused by heart failure). The infant did not survive. [4] Signs of hemolytic disease of the newborn include a positive direct Coombs test (also called direct agglutination test), elevated cord bilirubin levels, and hemolytic anemia.
Bilirubin should be tested from cord blood. [1] Ferritin - because most infants affected by HDN have iron overload, a ferritin must be run before giving the infant any additional iron. [7] Newborn Screening Tests - Transfusion with donor blood during pregnancy or shortly after birth can affect the results of the Newborn Screening Tests.
772.9 Unspecified hemorrhage of newborn; 773 Hemolytic disease of fetus or newborn, due to isoimmunization. 773.0 Hemolytic disease, RH isoimmunization; 773.1 Hemolytic disease, ABO isoimmunization; 774 Other perinatal jaundice. 774.2 Jaundice, newborn, prematurity; 774.3 Jaundice, newborn, unspec. 774.3 Lucey-Driscoll syndrome. 774.39 Jaundice ...
These evidence-based guidelines cover topics like fetal heart rate monitoring, labor induction, neonatal skin care, [4] care of the late preterm infant, [5] breastfeeding, HPV counseling, neonatal hyperbilirubinemia, nursing staffing, [6] and care of the patient in the second stage of labor.
Bilirubin should be tested from cord blood. [5] Ferritin - because most infants affected by HDN have iron overload, ferritin levels must be measured before giving the infant any additional iron. [11] Newborn Screening Tests - Transfusion with donor blood during pregnancy or shortly after birth can affect the results of the Newborn Screening Tests.