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Exertional rhabdomyolysis, the exercise-induced muscle breakdown that results in muscle pain/soreness, is commonly diagnosed using the urine myoglobin test accompanied by high levels of creatine kinase (CK). Myoglobin is the protein released into the bloodstream when skeletal muscle is broken down. The urine test simply examines whether ...
Rhabdomyolysis may cause kidney failure by several mechanisms. The most important is the accumulation of myoglobin in the kidney tubules . [ 10 ] [ 11 ] [ 13 ] Normally, the blood protein haptoglobin binds circulating myoglobin and other heme-containing substances, but in rhabdomyolysis the quantity of myoglobin exceeds the binding capacity of ...
Back pain is present in 29% of patients with systemic cancer. [19] Unlike other causes of back pain that commonly affect the lumbar spine, the thoracic spine is most commonly affected. [19] The pain can be associated with systemic symptoms such as weight loss, chills, fever, nausea and vomiting. [19]
Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of kidney problems, it can occlude the kidneys' filtration system leading to acute tubular necrosis and acute kidney injury. Other causes of myoglobinuria include: McArdle's disease
Lloyd's sign indicates the presence of renal calculus or pyelonephritis when pain is elicited by deep percussion in the back between the 12th rib and the spine. [1] It is closely related to costovertebral angle tenderness, as the area of percussion is the same. However, Lloyd's sign is specifically defined as positive costovertebral angle ...
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Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause: Pain in the back or side; Healthy kidneys produce the hormone erythropoietin that stimulates the bone marrow to make oxygen-carrying red blood cells. As the kidneys fail, they produce less erythropoietin, resulting in decreased ...
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