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Citrate synthase (E.C. 2.3.3.1 (previously 4.1.3.7)) is an enzyme that exists in nearly all living cells. It functions as a pace-making enzyme in the first step of the citric acid cycle (or Krebs cycle). [5] Citrate synthase is located within eukaryotic cells in the mitochondrial matrix, but is encoded by nuclear DNA rather than
In molecular biology, the citrate synthase family of proteins includes the enzymes citrate synthase EC 2.3.3.1, and the related enzymes 2-methylcitrate synthase EC 2.3.3.5 and ATP citrate lyase EC 2.3.3.8. Citrate synthase is a member of a small family of enzymes that can directly form a carbon-carbon bond without the presence of metal ion ...
ATP citrate synthase (also ATP citrate lyase (ACLY)) is an enzyme that in animals catalyzes an important step in fatty acid biosynthesis. [2] By converting citrate to acetyl-CoA , the enzyme links carbohydrate metabolism , which yields citrate as an intermediate , with fatty acid biosynthesis , which consumes acetyl-CoA. [ 3 ]
Oxoglutarate dehydrogenase is a key control point in the citric acid cycle. It is inhibited by its products, succinyl CoA and NADH.A high energy charge in the cell will also be inhibitive.
N 2-citryl-N 6-acetyl-N 6-hydroxylysine synthase (EC 6.3.2.38, N(alpha)-citryl-N(epsilon)-acetyl-N(epsilon)-hydroxylysine synthase, iucA (gene)) is an enzyme with systematic name citrate:N 6-acetyl-N 6-hydroxy-L-lysine ligase (ADP-forming).
In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction acetyl-CoA + H 2 O + oxaloacetate ⇌ {\displaystyle \rightleftharpoons } citrate + CoA The 3 substrates of this enzyme are acetyl-CoA , H 2 O , and oxaloacetate , whereas its two products are citrate and CoA .
Aconitase (aconitate hydratase; EC 4.2.1.3) is an enzyme that catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle, a non-redox-active process.
In enzymology, a 2-methylcitrate synthase (EC 2.3.3.5) is an enzyme that catalyzes the chemical reaction propanoyl-CoA + H 2 O + oxaloacetate ⇌ {\displaystyle \rightleftharpoons } (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA