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Nicotinonitrile or 3-cyanopyridine is an organic compound with the formula NCC 5 H 4 N. The molecule consists of a pyridine ring with a nitrile group attached to the 3-position. A colorless solid, it is produced by ammoxidation of 3-methylpyridine: [2] H 3 CC 5 H 4 N + NH 3 + 1.5 O 2 → NCC 5 H 4 N + 3 H 2 O. Nicotinonitrile is a precursor to ...
In these conversions, chloride is displaced. [2] Pyrithione, the conjugate base of 2-mercaptopyridine-N-oxide, is a fungicide found in some shampoos. Oxidation 2-chloropyridine gives 2-chloropyridine-N-oxide. [5] The antihistamine pheniramine may be generated via the reaction of phenylacetonitrile with 2-chloropyridine in the presence of a base ...
Chloropyridines are important intermediates to pharmaceuticals and agrochemicals. [1] A major use of 2-chloropyridine is the production of production of the fungicide pyrithione . Reaction of 4-chloropyridine with thioglycolic acid gives pyridylmercaptoacetic acid , a step in the production of cephalosporin antibiotics.
Related salts are also known, such as 1-butylpyridinium chlorochromate, [C 5 H 5 N(C 4 H 9)][CrO 3 Cl] and potassium chlorochromate. PCC is commercially available. Discovered by accident , [ 3 ] the reagent was originally prepared via addition of pyridine into a cold solution of chromium trioxide in concentrated hydrochloric acid : [ 4 ]
Pyridine-N-oxide is the heterocyclic compound with the formula C 5 H 5 NO. This colourless, hygroscopic solid is the product of the oxidation of pyridine. It was originally prepared using peroxyacids as the oxidising agent. The compound is used infrequently as an oxidizing reagent in organic synthesis. [1]
3-Chloropyridine is an aryl chloride and isomer of chloropyridine with the formula C 5 H 4 ClN. It is a colorless liquid that is mainly used as a building block in organic synthesis. [1] The compound is a substrate for many coupling processes including the Heck reaction, [2] Suzuki reaction, [3] and Ullmann reaction. [4]
2,6-Dichloropyridine is a chloropyridine with the formula C 5 H 3 Cl 2 N. A white solid, it is one of six isomers of dichloropyridine . It serves as a precursor to the antibiotic enoxacin , [ 2 ] as well as the drug and anpirtoline and the antifungal liranaftate .
Cyanuric chloride is employed as a reagent in organic synthesis for the conversion of alcohols into alkyl chlorides, [8] and carboxylic acids into acyl chlorides: [9]. It is also used as a dehydrating agent, e.g. in the conversion of amides to nitriles, [10] and for the activation of carboxylic acids for reduction to alcohols.