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  2. p53 upregulated modulator of apoptosis - Wikipedia

    en.wikipedia.org/wiki/P53_upregulated_modulator...

    Even though PUMA function is compromised in most cancer cells, it does not appear that genetic inactivation of PUMA is a direct target of cancer. [ 36 ] [ 37 ] [ 38 ] Many cancers do exhibit p53 gene mutations, making gene therapies that target this gene [ clarification needed ] impossible, but an alternate pathway may be to focus on ...

  3. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    Recent studies show that p53 isoforms are differentially expressed in different human tissues, and the loss-of-function or gain-of-function mutations within the isoforms can cause tissue-specific cancer or provide cancer stem cell potential in different tissues.

  4. Suicide gene - Wikipedia

    en.wikipedia.org/wiki/Suicide_gene

    In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.

  5. Apoptosis - Wikipedia

    en.wikipedia.org/wiki/Apoptosis

    In order for apoptosis to occur within OROV, viral uncoating, viral internalization, along with the replication of cells is necessary. Apoptosis in some viruses is activated by extracellular stimuli. However, studies have demonstrated that the OROV infection causes apoptosis to be activated through intracellular stimuli and involves the ...

  6. Burkitt lymphoma - Wikipedia

    en.wikipedia.org/wiki/Burkitt_lymphoma

    These additional mutations include mutations of the tumor suppressor TP53, which interacts with the tumor suppressor p53 (which usually causes apoptosis in B cells carrying the disordered MYC oncoprotein). But with TP53 and p53 mutated, apoptosis is blocked, and the oncogenic B-cells are allowed to proliferate unchecked. [3]

  7. UVB-induced apoptosis - Wikipedia

    en.wikipedia.org/wiki/UVB-induced_apoptosis

    Apoptosis is a physiological process, that promotes the active suicide of cells, resulting in an advantage, unlike necrosis which occurs from trauma. In the average human adult it is estimated that 50 to 70 billion cells die each day from apoptosis. One of the largest promoters of apoptosis is exposure to ultraviolet (UV) light.

  8. DNA damage (naturally occurring) - Wikipedia

    en.wikipedia.org/wiki/DNA_damage_(naturally...

    p53 is a major key player in the growth of cancerous cells. Damaged DNA cells with mutated p53 are at a higher risk of becoming cancerous. Common chemotherapy treatments are genotoxic. These treatments are ineffective in cancer tumor that have mutated p53 since they do not have a functioning p53 to either arrest or kill the damaged cell.

  9. BH3 interacting-domain death agonist - Wikipedia

    en.wikipedia.org/wiki/BH3_interacting-domain...

    The expression of BID is upregulated by the tumor suppressor p53, and BID has been shown to be involved in p53-mediated apoptosis. [7] The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including BID. However, p53 also has a transcription-independent ...

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