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  2. Bristol Myers' schizophrenia drug reduces symptoms without ...

    www.aol.com/news/bristol-myers-schizophrenia...

    Bristol Myers Squibb said on Saturday data from late-stage studies of its experimental schizophrenia drug showed it helped reduce symptoms of the disorder without the common side effect of weight ...

  3. Olanzapine - Wikipedia

    en.wikipedia.org/wiki/Olanzapine

    Although antagonistic effects of olanzapine at 5-HT 2C alone are not associated with weight gain, olanzapine antagonism at histaminergic H 1, and muscarinic M 3 receptors have been implicated in weight gain. [92] [103] [104] The mode of action of olanzapine's antipsychotic activity is unknown. It may involve antagonism of dopamine and serotonin ...

  4. Olanzapine/samidorphan - Wikipedia

    en.wikipedia.org/wiki/Olanzapine/samidorphan

    [1] [2] [3] Samidorphan reduces the weight gain associated with olanzapine while still allowing olanzapine to exert its therapeutic effect. [4] [5] Although Lybalvi still produces transient weight gain of roughly 11 pounds, its metabolic profile is significantly lower than olanzapine alone. The formulation was approved for medical use in the ...

  5. Samidorphan - Wikipedia

    en.wikipedia.org/wiki/Samidorphan

    A Phase III study found that the addition of samidorphan to olanzapine significantly reduced weight gain compared to olanzapine alone, [15] and the combination was approved for the treatment of schizophrenia and bipolar disorder by the FDA in May 2021, under the brand name Lybalvi. [16] [17]

  6. Asenapine - Wikipedia

    en.wikipedia.org/wiki/Asenapine

    † Asenapine seems to have a relatively low weight gain liability for an atypical antipsychotic (which are notorious for their metabolic side effects) and a 2013 meta-analysis found significantly less weight gain (SMD [standard mean difference in weight gained in those on placebo vs. active drug]: 0.23; 95% CI: 0.07-0.39) than, paliperidone ...

  7. Quetiapine - Wikipedia

    en.wikipedia.org/wiki/Quetiapine

    Produces roughly as much weight gain as risperidone, less weight gain than clozapine, olanzapine and zotepine and more weight gain than ziprasidone, lurasidone, aripiprazole and asenapine. [22] As with many other atypical antipsychotics, this action is likely due to its actions at the H 1 histamine receptor and 5-HT 2C receptor. [10]

  8. Molindone - Wikipedia

    en.wikipedia.org/wiki/Molindone

    The drug is sometimes described as a typical antipsychotic, [5] and sometimes described as an atypical antipsychotic. [6] Chemically, molindone is an indole and is structurally distinct from many other antipsychotics. [2] Molindone was first described by 1966 [7] and was introduced for medical use in 1974. [8] It remains marketed only in the ...

  9. What is metformin, the old diabetes drug some people are ...

    www.aol.com/lifestyle/metformin-old-diabetes...

    Metformin is also sometimes prescribed to help prevent excess weight gain for people taking antipsychotic medications, for which weight gain is a common ... At nearly $1,000 without insurance, ...