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  2. Polysulfated glycosaminoglycan - Wikipedia

    en.wikipedia.org/wiki/Polysulfated_glycosaminoglycan

    The glycosaminoglycan side chains are polyanionic, which causes adjacent side chains to push each other away and create a "bottle brush", where hyaluronic acid is the stem and the side chains are the bristles. When pressure is exerted on the joint, fluids move between the chondrocytes and synovial fluid, exchanging nutrients. [4]

  3. Dog skin disorders - Wikipedia

    en.wikipedia.org/wiki/Dog_skin_disorders

    Dog with atopic dermatitis, with signs around the eye created by rubbing. Atopy is a hereditary [3] and chronic (lifelong) allergic skin disease. Signs usually begin between 6 months and 3 years of age, with some breeds of dog, such as the golden retriever, showing signs at an earlier age.

  4. Bedinvetmab - Wikipedia

    en.wikipedia.org/wiki/Bedinvetmab

    Half the dogs received bedinvetmab and half the dogs received a sterile saline injection every 28 days for a total of three doses. [5] Before treatment and on various days throughout the study, owners used the Canine Brief Pain Inventory (CBPI) assessment tool to measure the severity of the dog's pain and the degree to which the pain interfered ...

  5. Synovial fluid - Wikipedia

    en.wikipedia.org/wiki/Synovial_fluid

    Synovial fluid, also called synovia, is a viscous, non-Newtonian fluid found in the cavities of synovial joints. With its egg white –like consistency, [ 1 ] the principal role of synovial fluid is to reduce friction between the articular cartilage of synovial joints during movement. [ 2 ]

  6. Glycosaminoglycan - Wikipedia

    en.wikipedia.org/wiki/Glycosaminoglycan

    In the clinic, heparin is administered as an anticoagulant and is also the first line choice for thromboembolic diseases. [ 14 ] [ 15 ] Heparan sulfate (HS) has numerous biological activities and functions, including cell adhesion, regulation of cell growth and proliferation, developmental processes, cell surface binding of lipoprotein lipase ...

  7. Transient synovitis - Wikipedia

    en.wikipedia.org/wiki/Transient_synovitis

    Treatment consists of rest, non-weightbearing and painkillers when needed. A small study showed that the nonsteroidal anti-inflammatory drug ibuprofen could shorten the disease course (from 4.5 to 2 days) and provide pain control with minimal side effects (mainly gastrointestinal disturbances ). [ 25 ]

  8. Stifle joint - Wikipedia

    en.wikipedia.org/wiki/Stifle_joint

    This dog's stifle joint is labeled 12. The stifle joint (often simply stifle) is a complex joint in the hind limbs of quadruped mammals such as the sheep, horse or dog. It is the equivalent of the human knee and is often the largest synovial joint in the animal's body. The stifle joint joins three bones: the femur, patella, and tibia.

  9. Trilostane - Wikipedia

    en.wikipedia.org/wiki/Trilostane

    Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...