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Valproate may cause increased somnolence in the elderly. In a trial of valproate in elderly patients with dementia, a significantly higher portion of valproate patients had somnolence compared to placebo. In approximately one-half of such patients, there was associated reduced nutritional intake and weight loss.
But in people with dementia—which is an umbrella term for mental decline and can be related to a number of diseases such as Alzheimer's—there’s a phenomenon known as “sundowning,” where ...
The onset of dementia can come as a shock, but various signs could predict the condition as long as 20 years before symptoms. A new study published by the RAND Corporation in California identified ...
The first symptoms are often mistakenly attributed to aging or stress. [34] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for diagnosis of Alzheimer's disease. [35] These early symptoms can affect the most complex activities of daily living. [36]
Dementia is a devastating condition that impacts almost 10% of older adults in the U.S. With that, it’s understandable to want to do what you can to lower the risk of developing it in the future.
LATE is a term that describes a prevalent medical condition with impaired memory and thinking in advanced age, often culminating in the dementia clinical syndrome. [1] In other words, the symptoms of LATE are similar to those of Alzheimer's disease. The acronym LATE stands for Limbic-predominant Age-related TDP-43 Encephalopathy.
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