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NSAIDS are a nonspecific medication used for abortion of migraines due to their analgesic properties. They can be used for mild to moderate migraines, but are less effective against severe migraines. [8] Similar to the triptans and ergots alkaloids, their use should be limited to less than 10x per month to reduce MOH.
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours [3] and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment.
Newer approaches: C.G.R.P. antibodies, which are once-monthly injections, and Botox injections help block the pathways in the brain that are used during a migraine attack.
A migraine attack often causes severe throbbing pain or a pulsing sensation, usually on one side of the head. But migraine attacks are complex, and not everyone will have the same set of symptoms.
A test measuring a person's skin sensitivity during a migraine may indicate whether the individual will respond to treatment with triptans. [7] Triptans are most effective in those with no skin sensitivity; with skin sensitivity, it is best to take triptans within twenty minutes of the headache's onset. [8]
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