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The human cerebellum is located at the base of the brain, with the large mass of the cerebrum above it, and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of tough dura mater called the cerebellar tentorium; all of its connections with other parts of the brain travel through the pons.
The cerebellar cortex is divided into three layers. At the bottom lies the thick granular layer, densely packed with granule cells, along with interneurons, mainly Golgi cells but also including Lugaro cells and unipolar brush cells.
The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres.
It is connected to the brainstem by three pairs of nerve tracts called cerebellar peduncles. The superior pair connects to the midbrain; the middle pair connects to the medulla, and the inferior pair connects to the pons. [33] The cerebellum consists of an inner medulla of white matter and an outer cortex of richly folded grey matter. [35]
It includes the medulla, pons, and cerebellum. Myelencephalon. Medulla oblongata. Medullary pyramids; ... This page was last edited on 3 January 2025, ...
The cerebellum, or "little brain," is a portion of the brain attached to the brainstem at the pons. Among other functions, it is important for balance, coordinating movement, and maintaining muscle tone. [5] The outer layer of the cerebellum, the cortex, is made up of three layers containing two classes of neurons.
Cerebellar granule cells receive excitatory input from 3 or 4 mossy fibers originating from pontine nuclei. Mossy fibers make an excitatory connection onto granule cells, which causes the granule cells to fire an action potential. The axon of a cerebellar granule cell splits to form a parallel fiber which innervates Purkinje cells. The vast ...
The Purkinje layer of the cerebellum, which contains the cell bodies of the Purkinje cells and Bergmann glia, express a large number of unique genes. [9] Purkinje-specific gene markers were also proposed by comparing the transcriptome of Purkinje-deficient mice with that of wild-type mice. [10]