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Members of the GABA receptor family, especially GABRB3, are attractive candidate genes for Autism because of their function in the nervous system. GABRB3 null mice exhibit behaviors consistent with autism [ 29 ] and multiple genetic studies have found significant evidence for association. [ 30 ]
This gene is also a candidate for autism because of the physiological response that benzodiazepine has on the GABA-A receptor, when used to treat seizures and anxiety disorders. [6] The Gabrb3 gene deficient mouse has been proposed as a model of autism spectrum disorder. [13]
Research programme: autism and obesity therapeutics - Berand Neuropharmacology – histone deacetylase inhibitors [61] Research programme: brain development disorder therapeutics - Seaside Therapeutics (STX-110) – metabotropic glutamate mGlu 5 receptor antagonists and muscarinic acetylcholine M 1 receptor antagonists [62]
MU Thompson Center research finds a generic blood pressure drug reduces anxiety in people with autism spectrum disorder.
The etiology of autism may include excessive glutamatergic mechanisms. In small studies, memantine has been shown to significantly improve language function and social behavior in children with autism. [57] [58] Research is underway on the effects of memantine in adults with autism spectrum disorders. [59]
The review found that CBT was moderately to highly effective at reducing anxiety in school children with autism spectrum disorder, but that effects varied depending on whether they were reported by clinicians, parents or self-reported. Treatments involving parents and one-on-one compared to group treatments were more effective. [12]
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
The GABA system, including the GABRD gene, is implicated in the regulation of anxiety and stress responses. While there is ongoing research to understand the complex genetic and neurobiological factors contributing to anxiety disorders, it's important to note that anxiety is a multifaceted condition influenced by a combination of genetic ...
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