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They have been marketed as herbal incense, or "herbal smoking blends", [6] and sold under common names like K2, spice, [8] and synthetic marijuana. [5] They are often labeled "not for human consumption" for liability defense. [ 8 ]
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Hundreds of other designer drugs or "legal highs" have been reported, including artificial chemicals such as synthetic cannabis and semi-synthetic substances such as methylhexaneamine. [49] These drugs are primarily developed to avoid being controlled by laws against illegal drugs, thus giving them the label designer drugs .
It was often sold in legal smoke blends collectively known as "spice". Several countries and states have moved to ban it legally. JWH-073; CP-55940, produced in 1974, this synthetic cannabinoid receptor agonist is many times more potent than THC. Dimethylheptylpyran; HU-210, about 100 times as potent as THC [101]
In the US, the states of Kansas, Georgia, Alabama, Tennessee, Missouri, Louisiana, Mississippi, Arkansas, and New York banned K2, herbal incense. JWH-018 was banned by controlled substances act on December 21, 2012. Law enforcement officials in Canada asked Huffman to serve as a consultant and expert witness.
Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65).
Cannabicyclohexanol (CCH, CP 47,497 dimethyloctyl homologue, (C8)-CP 47,497) is a cannabinoid receptor agonist drug, developed by Pfizer in 1979. On 19 January 2009, the University of Freiburg in Germany announced that an analog of CP 47,497 was the main active ingredient in the herbal incense product Spice, specifically the 1,1-dimethyloctyl homologue of CP 47,497, which is now known as ...
High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, [13] and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. [13] It has also been repeatedly noted to induce irresistible cravings to re-administer. [13] [14]
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