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We compared the effectiveness of cefixime in eliminating N. gonorrhoeae infection at the 3 anatomical sites (urogenital, pharyngeal, and rectal). We performed the analysis separately by dosage (single cefixime dose of 400 or 800 mg).
Cefixime 800 mg orally as a single dose. If treating with cefixime, and chlamydial infection has not been excluded, providers should treat for chlamydia with doxycycline 100 mg orally twice daily for 7 days.
Although clinical data confirm that a single injection of ceftriaxone 250 mg is >99% (95% confidence interval [CI]: 97.6%–99.7%) effective in curing anogenital gonorrhea of circulating isolates (MIC = 0.03 µg/mL), a higher dose is likely necessary for isolates with elevated MICs (880,881).
At present, the only CDC-recommended treatment of uncomplicated urogenital, anorectal, and pharyngeal gonorrhea is monotherapy with a single intramuscular dose of ceftriaxone 500 mg. If the recommended injectable treatment is not possible, then EPT via a single dose of 800mg cefixime should be considered.
A single dose of 400 mg cefixime orally taken once coupled with 2 g of azithromycin is recommended as an alternative treatment option for uncomplicated gonorrhea. However, in patients where IM injection are contraindicated in conditions such as hemophilia, or patients under therapy with anticoagulants, it might prove as a useful alternative to ...
SUMMARY. Dual treatment with ceftriaxone 250 mg intramuscularly as a single dose and azithromycin 1 g orally as a single dose is recommended for the treatment of uncomplicated gonorrhea of the urethra, cervix, rectum, or pharynx.
Cefixime 800 mg PO and performing test of cure. Single-drug therapy (one of the following, based on recent local resistance data confirming susceptibility to the antimicrobial): Ceftriaxone 1g...
For expedited partner therapy (EPT) to treat partners of patients who have tested positive for gonorrhea, the recommended dosages are 800 mg cefixime in a single dose and doxycycline, 100 mg twice daily for seven (7) days. If adherence is an issue, 2 grams of azithromycin in a single dose can be prescribed instead of doxycycline.
If test of cure is not possible or when oropharyngeal infection is diagnosed or is a potential concern, WHO suggests: cefixime 800 mg orally plus azithromycin 2 g orally. When resistance, allergy or availability of cephalosporins is a concern, WHO suggests one of the following options:
Although it is an alternative regimen, expedited partner therapy with single-dose cefixime (Suprax), 800 mg orally, can be used to treat sex partners of those with gonorrheal infection.