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  2. Sirolimus - Wikipedia

    en.wikipedia.org/wiki/Sirolimus

    Ultimately, due to known side-effects of sirolimus, as well as inadequate evidence for optimal dosing, it was concluded in 2016 that more research was required before sirolimus could be widely prescribed for this purpose. [68] [73] Two human studies on the effects of sirolimus (rapamycin) on longevity did not show statistically significant ...

  3. Immunosuppressive drug - Wikipedia

    en.wikipedia.org/wiki/Immunosuppressive_drug

    Sirolimus (rapamycin, trade name Rapamune) is a macrolide lactone, produced by the actinomycete bacterium Streptomyces hygroscopicus. It is used to prevent rejection reactions. Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects.

  4. mTOR inhibitors - Wikipedia

    en.wikipedia.org/wiki/MTOR_inhibitors

    mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...

  5. Autoimmune lymphoproliferative syndrome - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_lymphoprolife...

    It is mostly well tolerated (though side effects include mucositis, diarrhea, hyperlipidemia, delayed wound healing) with drug-drug interactions. It has better activity against autoimmune disease and lymphoproliferation than mycophenolate mofetil and other drugs; however, sirolimus requires therapeutic drug monitoring and can cause mucositis.

  6. Serious Ozempic Side Effects, Confirmed: Here’s What to Know

    www.aol.com/serious-ozempic-side-effects...

    A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.

  7. Ozempic Butt Isn't The Strangest Side Effect Of The Drug ...

    www.aol.com/ozempic-butt-isnt-strangest-side...

    Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or even gallstones, Dr. Comite says.

  8. Tacrolimus - Wikipedia

    en.wikipedia.org/wiki/Tacrolimus

    Side effects can be severe and include infection, cardiac damage, hypertension, blurred vision, liver and kidney problems (tacrolimus nephrotoxicity), [26] hyperkalemia, hypomagnesemia, hyperglycemia, diabetes mellitus, itching, lung damage (sirolimus also causes lung damage), [27] and various neuropsychiatric problems such as loss of appetite ...

  9. TNF inhibitor - Wikipedia

    en.wikipedia.org/wiki/TNF_inhibitor

    A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their ...

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