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In November 2017, the FDA approved Abilify MyCite, a digital pill containing a sensor intended to record when its consumer takes their medication. [138] [139] A long-acting injectable version of aripiprazole was approved by the FDA for the treatment of bipolar disorder 1 and schizophrenia in April 2023. [140] [141] [142]
Aripiprazole lauroxil, sold under the brand name Aristada, is a long-acting injectable atypical antipsychotic that was developed by Alkermes. [3] [4] [5] It is an N-acyloxymethyl prodrug of aripiprazole that is administered via intramuscular injection once every four to eight weeks for the treatment of schizophrenia.
Aripiprazole (Abilify) - Partial agonist at the D 2 receptor. Considered the prototypical third-generation antipsychotic. [169] Aripiprazole lauroxil (Abilify Maintena) – Long-acting version of aripiprazole for injection. Brexpiprazole (Rexulti) – Partial agonist of the D 2 receptor. Successor of aripiprazole.
Brexpiprazole was developed by Otsuka and Lundbeck, and is considered to be a successor to aripiprazole (Abilify). [15] It was approved for medical use in the United States in July 2015. [ 16 ] [ 17 ] A generic version was approved in August 2022. [ 18 ]
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Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
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