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They also developed a highly efficient and robust model for studying how HCC development is promoted by the common metabolic disorder non-alcoholic steatohepatitis (NASH). Using the so-called MUP-uPA mouse they demonstrated that NASH development depends on ER stress and TNF-mediated inflammation.
The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. [ 2 ] The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory ...
Each copy of "Merry Happy" had a number from 1–1000 printed on it. A competition was held on the official Kate Nash website, where fans who bought a copy of 'Merry Happy' with a winning number on it would win the chance for Kate Nash to customize their copy for them. The 10 winning numbers were posted on katenash.co.uk.
A further nutrigenomics model named multiple hit extends the second hit model, suggesting that multiple disease biomarkers and factors such as genes and nutrition influence NAFLD and NASH progression. This model attempts to use these factors to predict the impact of lifestyle changes and genetics for the evolution of the NAFLD pathology. [52]
The Dp(16)1Yu model (also referred to as Dp(16)1Yey) contains a partial duplication of the mouse chromosome 16 (MMU16). Unlike the Ts65Dn model, Dp(16)1Yu contains a duplication of only the parts of chromosome 16 that are homologous to human chromosome 21. This makes the Dp(16)1Yu model a more genetically accurate representation of Down Syndrome.
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The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.