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Serotonin antagonist and reuptake inhibitors (SARIs) are a class of drugs used mainly as antidepressants, but also as anxiolytics and hypnotics. They act by antagonizing serotonin receptors such as 5-HT 2A and inhibiting the reuptake of serotonin, norepinephrine, and/or dopamine. Additionally, most also antagonize α 1-adrenergic receptors.
In fact, since SSRIs are typically better tolerated with a lower risk of side effects, some studies have shown that fewer patients discontinue SSRI therapy than with alternative antidepressants.
Side effects from all antidepressants can affect anyone, so if you’re struggling with anything from (mild) dry mouth to (serious) suicidal thoughts, talk to your healthcare provider immediately. ...
Side effects. SSRIs are generally less likely to cause side effects than older antidepressants, but adverse effects still happen for some people. Common SSRI side effects include nausea, agitation ...
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 83 ] [ 85 ] [ 86 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 83 ]
For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.
Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as erectile dysfunction ...
The SSRIs also have less affinity for α 1, α 2, H 1 and muscarinic receptors, which might explain the differences of adverse events between TCAs and SSRIs. [ 6 ] Although SSRIs arrive rapidly to the brain after administration and the effects on 5-HT re-uptake can be measured instantly, it takes about 2–4 weeks to get therapeutic effects ...
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