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Efavirenz may be used, but dose used depends on the patient's weight (600 mg daily if weight less than 50 kg; 800 mg daily if weight greater than 50 kg). Efavirenz levels should be checked early after starting treatment (unfortunately, this is not a service routinely offered in the US, but is readily available in the UK).
The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
Dose optimization and target attainment of vancomycin in children involves adjusting the dosage to maximize effectiveness while minimizing the risk of adverse effects, specifically acute kidney injury. Dose optimization is achieved by therapeutic drug monitoring (TDM), which allows measurement of vancomycin levels in the blood.
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Approved for weight management (short-term) by the FDA but not the European Medicines Agency [54] 10% [55] or 8.25 kilograms (18.2 lb) [56] Naltrexone/bupropion: Contrave Approved for weight management (chronic) in the US and EU [57] 5 percent [17] Liraglutide: Saxenda GLP-1 receptor agonist: Approved for weight management (chronic) 4 percent ...
The BNF for Children developed from the British National Formulary (BNF), which prior to 2005 had provided information on the treatment of children, with the doses largely determined by calculations based on the body weight of the child. The guidance was provided by pharmacists and doctors whose expertise was in the care of adults.
In 2005, the innovative Weigh Smart® program was added as a multi-disciplinary and holistic approach to pediatric weight management. It was followed in (2009) by Weigh Smart Jr. ® designed for weight management of toddlers and preschool-aged children and also involving medical, nutritional, educational and behavioral components.
An example for a simple case (mono-compartmental) would be to administer D=8 mg/kg to a human. A human has a blood volume of around V b l o o d = {\displaystyle V_{blood}=} 0.08 L/kg . [ 7 ] This gives a C 0 = {\displaystyle C_{0}=} 100 μg/mL if the drug stays in the blood stream only, and thus its volume of distribution is the same as V b l o ...