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  2. Chronic kidney disease in cats - Wikipedia

    en.wikipedia.org/wiki/Chronic_kidney_disease_in_cats

    Cats are carnivores. The kidney is a vital organ with a variety of tasks. It plays an important role in maintaining the water, electrolyte and acid-base balance, in the excretion of toxic metabolic degradation products such as urea and in the recovery of valuable substances such as glucose, amino acids, peptides and minerals initially filtered out of the blood during ultrafiltration in the ...

  3. Maropitant - Wikipedia

    en.wikipedia.org/wiki/Maropitant

    Maropitant undergoes 1st-pass metabolism by liver enzymes, mainly CYP2D15 (which has high affinity for maropitant and clears over 90% of it) but also by the lower-affinity CYP3A12. [ 11 ] [ 12 ] Repeat dosing of maropitant eventually saturates CYP2D15, causing the drug to accumulate due to reduced clearance. [ 5 ]

  4. Capromorelin - Wikipedia

    en.wikipedia.org/wiki/Capromorelin

    Capromorelin, sold under the brand names, Entyce and Elura, is a medication used for the management of weight loss in cats and dogs. [5] [6] Capromorelin is a ghrelin receptor agonist known to increase appetite and weight gain. [2] Capromorelin was developed by Pfizer. [7] [8] Capromorelin was approved for veterinary use in the United States in ...

  5. Alfaxalone - Wikipedia

    en.wikipedia.org/wiki/Alfaxalone

    Alfaxalone is used as an induction agent, an injectable anesthetic, and a sedative in animals. [5] While it is commonly used in cats and dogs, it has also been successfully used in rabbits, [6] horses, sheep, pigs, and exotics such as red-eared turtles, axolotl, green iguanas, marmosets, [7] and koi fish. [8]

  6. GS-441524 - Wikipedia

    en.wikipedia.org/wiki/GS-441524

    Since untreated feline infectious peritonitis (FIP) is fatal in almost all cases [9] and in most countries there are no approved treatments available, GS-441524 has reportedly been sold illegally worldwide on the black market and used by pet owners to treat affected cats, although Gilead Sciences has refused to license the drug for veterinary use.

  7. Probenecid - Wikipedia

    en.wikipedia.org/wiki/Probenecid

    Probenicid lowers the concentration of certain drugs in urine drug screens by reducing renal excretion of these drugs. Historically, probenecid has been used to increase the duration of action of drugs such as penicillin and other beta-lactam antibiotics. Penicillins are excreted in the urine at proximal and distal convoluted tubules through ...

  8. Metolazone - Wikipedia

    en.wikipedia.org/wiki/Metolazone

    Its creator, Indian born chemist Dr. Bola Vithal Shetty has been active in helping the U.S. Food and Drug Administration review drug applications, and in the development of new medicines. [6] Metolazone quickly gained popularity due to its lower kidney toxicity compared to other diuretics (especially thiazides) in patients with chronic kidney ...

  9. Nephrotoxicity - Wikipedia

    en.wikipedia.org/wiki/Nephrotoxicity

    In interventional radiology, a patient's creatinine clearance levels are all checked prior to a procedure. [citation needed] Serum creatinine is another measure of kidney function, which may be more useful clinically when dealing with patients with early kidney disease. Normal creatinine level is between 80 - 120 μmol/L. [citation needed]

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