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Magic bullet (medicine) The magic bullet is a scientific concept developed by the German Nobel laureate Paul Ehrlich in 1907. [ 1 ] While working at the Institute of Experimental Therapy (Institut für experimentelle Therapie), Ehrlich formed an idea that it could be possible to kill specific microbes (such as bacteria), which cause diseases in ...
Paul Ehrlich. Paul Ehrlich (German: [ˈpaʊl ˈʔeːɐ̯lɪç] ⓘ; 14 March 1854 – 20 August 1915) was a Nobel Prize -winning German physician and scientist who worked in the fields of hematology, immunology and antimicrobial chemotherapy. Among his foremost achievements were finding a cure for syphilis in 1909 and inventing the precursor ...
Arsphenamine. The structure of arsphenamine has been proposed to be akin to azobenzene (A), but chemical studies published in 2005 suggest [1] that salvarsan is actually a mixture of the trimer (B) and the pentamer (C). Arsphenamine, also known as Salvarsan or compound 606, is an antibiotic drug that was introduced at the beginning of the 1910s ...
Monoclonal antibody. A general representation of the method used to produce monoclonal antibodies [1] [2] A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
Dr. Ehrlich's Magic Bullet. Dr. Ehrlich's Magic Bullet is a 1940 American biographical film starring Edward G. Robinson and directed by William Dieterle, based on the true story of the German doctor and scientist Dr. Paul Ehrlich. The film was released by Warner Bros., with some controversy over raising the subject of syphilis in a major studio ...
The mononuclear spot test or monospot test, a form of the heterophile antibody test, [1] is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV). It is an improvement on the Paul–Bunnell test. [2] The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection.
Although no approved therapeutics are currently based on ricin, it does have the potential to be used in the treatment of tumors, as a "magic bullet" to destroy targeted cells. [14] Because ricin is a protein, it can be linked to a monoclonal antibody to target cancerous cells recognized by the antibody.
A bispecific monoclonal antibody (BsMAb, BsAb) is an artificial protein that can simultaneously bind to two different types of antigen or two different epitopes on the same antigen. [ 1 ] Naturally occurring antibodies typically only target one antigen. BsAbs can be manufactured in several structural formats.
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