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These oxidative molecules can cause oxidative brain damage. Iron that is bound to ferritin in nonreactive. [1] Fenton Reaction (1) Fe 2+ + H 2 O 2 → Fe 3+ + HO• + OH − (2) Fe 3+ + H 2 O 2 → Fe 2+ + HOO• + H + The ferritin protein is made up of heavy chain (H) and light chain (L) subunits. In neuroferritinopathy, the gene encoding the ...
However ferritin levels may be elevated due to a variety of other causes including obesity, infection, inflammation (as an acute phase protein), chronic alcohol intake, liver disease, kidney disease, and cancer. [7] [32] [33] In males and postmenopausal females, normal range of serum ferritin is between 12 and 300 ng/mL (670 pmol/L) .
The ferritin levels measured usually have a direct correlation with the total amount of iron stored in the body. However, ferritin levels may be artificially high in cases of anemia of chronic disease, where ferritin is elevated in its capacity as an inflammatory acute phase protein and not as a marker for iron overload. [citation needed]
The reason why dehydration can cause lightheadedness is because it can lead to reduced blood pressure and prevent ... “If you are a high-risk patient—older than 50 years old, have a history of ...
This can cause lightheadedness in some people. In postural orthostatic tachycardia syndrome (POTS), the lightheadedness also comes with a rapid increase in heartbeat. Taking medications or ...
Iron deficiency can also cause shortness of breath, and amplify the symptoms of any chronic condition, such as depression. It can also have an affect on your mood, ability to focus and sleep quality .
Lightheadedness often accompanies the flu, hypoglycaemia, common cold, or allergies. Dizziness could be provoked by the use of antihistamine drugs, like levocetirizine, or by some antibiotics or SSRIs. Nicotine or tobacco products can cause lightheadedness for inexperienced users. Narcotic drugs, such as codeine, can also cause lightheadedness.
Diagnosis is based upon identification of symptoms, medical history, family history, and laboratory tests. Blood tests may show high levels of ferritin and low, normal, or high levels of transferrin saturation, depending on the form of hemochromatosis. The diagnosis must be confirmed by genetic testing for SLC40A1 mutations. [14]