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Zonisamide is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. The precise mechanism by which zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium and T-type calcium channels , which leads to the suppression of neuronal hypersynchronization ...
Ziconotide was discovered in the early 1980s by University of Utah research scientist Michael McIntosh, [3] when he was barely out of high school and working with Baldomero Olivera. [ 4 ] Ziconotide was developed into an artificially manufactured drug by Elan Corporation.
A period 5 element is one of the chemical elements in the fifth row (or period) of the periodic table of the chemical elements.The periodic table is laid out in rows to illustrate recurring (periodic) trends in the chemical behaviour of the elements as their atomic number increases: a new row is begun when chemical behaviour begins to repeat, meaning that elements with similar behaviour fall ...
Men can do the same,” says Alex Robboy, a sex therapist in Philadelphia. Essentially, kegel exercises are a way of contracting the muscles of the pelvic floor, which give you greater control and ...
That same year, however, Herrington and Lingle found no such effect at concentrations of up to 2.5 mmol/L. [19] The year after, a study conducted on human neocortical cells removed during surgery for intractable epilepsy, the first to use human tissue, found that ethosuximide had no effect on Ca 2+ currents at the concentrations typically ...
Bupropion/zonisamide (former tentative brand name Empatic, Excalia) is an experimental combination of bupropion which was under development for the treatment of obesity. [1] [2] [3] Bupropion is a norepinephrine–dopamine reuptake inhibitor and nicotinic acetylcholine receptor antagonist, while zonisamide is an anticonvulsant acting as a sodium channel blocker, T-type calcium channel blocker ...
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Male development can only occur when the fetal testis secretes key hormones at a critical period in early gestation. The testes begin to secrete three hormones that influence the male internal and external genitalia: they secrete anti-Müllerian hormone (AMH), testosterone, and dihydrotestosterone (DHT). Anti-Müllerian hormone causes the ...