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Permethrin is a medication and an insecticide. [6] [7] As a medication, it is used to treat scabies and lice. [8]It is applied to the skin as a cream or lotion. [6] As an insecticide, it can be sprayed onto outer clothing or mosquito nets to kill the insects that touch them.
The active ingredients are imidacloprid, permethrin, and pyriproxyfen. This product is toxic to cats, [2] and it is not recommended to use it on dogs which share an environment with cats. [1] The product is applied onto the skin; administration of the product into the mouth can cause adverse effects. [3]
[5] [6] [22] Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015. [23] For treating mites in chickens, a solution for use in drinking water is available under the brand name Exzolt [24] and was approved for use in the EU in 2017. [25]
Cypermethrin is very toxic to cats which cannot tolerate the therapeutic doses for dogs. [6] This is associated with UGT1A6 deficiency in cats, the enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses.
Poisoning can occur if pyrethroid containing flea treatment products, which are intended for dogs, are used on cats. The livers of cats detoxify pyrethroids via glucuronidation more poorly than dogs, which is the cause of this difference. [15] Aside from cats, pyrethroids are typically not toxic to mammals or birds. [16]
Permethrin can be applied as a spray. The effects are not limited to mites: lice, cockroaches, fleas, mosquitos, and other insects will be affected. Ivermectin can be prescribed by a medical doctor to rid humans of mite and lice infestations, and agricultural formulations are available for infested birds and rodents.
Phenothrin, also called sumithrin and d-phenothrin, [2] is a synthetic pyrethroid that kills adult fleas and ticks.It has also been used to kill head lice in humans. d-Phenothrin is used as a component of aerosol insecticides for domestic use.
However, diatomaceous earth dust is harmful to pets and people when inhaled, requiring use of a dust mask to apply. [8] [9] Bathing dramatically reduces the flea population on a badly infested animal, especially when in combination with a mild detergent or shampoo and brushing or combing. Borax can be used to treat flea infestations. It kills ...
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