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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
CA-125: Mainly ovarian cancer, [12] but may also be elevated in for example endometrial cancer, fallopian tube cancer, lung cancer, breast cancer and gastrointestinal cancer. [13] Calcitonin: medullary thyroid carcinoma [14] Calretinin: mesothelioma, sex cord-gonadal stromal tumor, adrenocortical carcinoma, synovial sarcoma [8] Carcinoembryonic ...
The study included 125 ambulatory male patients aged 4-8 years (63 in therapy group, 62 in placebo group). Mean motor function assessment score changes were 2.57 points in the Elevidys group and 1.92 points in the placebo group, with a non-significant difference of 0.65 points at the 52-week endpoint. [7]
CA-125 levels appear to fall during endometriosis treatment, but it has not shown a correlation with disease response. [ 121 ] Another review in 2011 identified several putative biomarkers upon biopsy, including findings of small sensory nerve fibers or defectively expressed β3 integrin subunit. [ 123 ]
Simufilam (PTI-125) is an experimental medication for the treatment of Alzheimer's disease. [ 2 ] [ 3 ] It was being developed by the American pharmaceutical firm Cassava Sciences . Development of simufilam was discontinued in November 2024 after it failed to show clinical benefit during phase III clinical trials .
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The results were promising but a number of patients demostrated immune responses and they had to withdraw from participating in the clinical trial. [28] The cT84.66 antibody was huminized and in 2020, a phase I clinical trial was performed during which 18 cancer patients received an injection of 90Y-DOTA-M5A. [ 29 ]
In 1966, John Money became the first American to employ chemical castration by prescribing medroxyprogesterone acetate (MPA) as a treatment for a "Bisexual transvestite with pedophiliac homosexual incest" who was in 'treatment' after their wife informed Money about them having sexually abused their 6-year-old son. [33]