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The LOD score (logarithm (base 10) of odds), developed by Newton Morton, [8] is a statistical test often used for linkage analysis in human, animal, and plant populations. The LOD score compares the likelihood of obtaining the test data if the two loci are indeed linked, to the likelihood of observing the same data purely by chance.
The test statistic LOD score linearly increases as the increase in population size. The larger of the QTL effect, the greater the corresponding LOD score increases. When population size is greater than 200, the position estimation of ICIM for QTL explaining more than 5% of the phenotypic variance is unbiased.
Linkage disequilibrium, often abbreviated to LD, is a term in population genetics referring to the association of genes, usually linked genes, in a population. It has become an important tool in medical genetics as well as other fields [ 1 ] [ 2 ]
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A DNA segment is identical by state (IBS) in two or more individuals if they have identical nucleotide sequences in this segment. An IBS segment is identical by descent (IBD) in two or more individuals if they have inherited it from a common ancestor without recombination, that is, the segment has the same ancestral origin in these individuals.
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A group of 58 researchers is calling for a new, better way to measure obesity.. The global team’s recommendations were published in The Lancet Diabetes & Endocrinology on Jan. 14.
A quantitative trait locus (QTL) is a locus (section of DNA) that correlates with variation of a quantitative trait in the phenotype of a population of organisms. [1] QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait.