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FRAX (fracture risk assessment tool) is a diagnostic tool used to evaluate the 10-year probability of bone fracture risk. It was developed by the University of Sheffield . [ 1 ]
Quantitative computed tomography (QCT) is a medical technique that measures bone mineral density (BMD) using a standard X-ray computed tomography (CT) scanner with a calibration standard to convert Hounsfield units (HU) of the CT image to bone mineral density values. [1]
The US National Osteoporosis Foundation recommends pharmacologic treatment for patients with hip or spine fracture thought to be related to osteoporosis, those with BMD 2.5 SD or more below the young normal mean (T-score -2.5 or below), and those with BMD between 1 and 2.5 SD below normal mean whose 10-year risk, using FRAX, for hip fracture is ...
Frailty Index (FI) = (number of health deficits present) ÷ (number of health deficits measured) For example, a person with 20 of 40 deficits collected has an FI score of 20/40 = 0.5; whilst for someone with 10 deficits, the FI score is 10/40 = 0.25. The FI takes advantage of the high redundancy in the human organism.
The trabecular bone score is a measure of bone texture correlated with bone microarchitecture and a marker for the risk of osteoporosis.Introduced in 2008, [1] its main projected use is alongside measures of bone density in better predicting fracture risk in people with metabolic bone problems.
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Frax is a robot in Ransik's service who constructs Cyclotrons to serve as foot soldiers. [8] [2] Due to Ransik abusing him and the Cyclotrons, Frax eventually rebels, revealing that he used to be Dr. Louis Ferricks, a human scientist who tried to help Ransik, only to be attacked by him and left for dead. Embittered by the betrayal, Ferricks ...
NRI attempts to quantify how well a new model correctly reclassifies subjects. Typically this comparison is between an original model (e.g. hip fractures as a function age and sex) and a new model which is the original model plus one additional component (e.g. hip fractures as a function of age, sex, and a genetic or proteomic biomarker).