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1α-Hydroxyvitamin D 5 is a chemical derivative of vitamin D 5.The motive to study 1α-hydroxyvitamin D 5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural metabolite produced in the kidney, to cause toxic hypercalcemia in patients when dosed at concentrations needed to interrupt prostate cancer cells' cycle and stimulate apoptosis.
[4]: 427 The normal range for blood concentration of 25-hydroxyvitamin D in adults is 20 to 50 nanograms per milliliter (ng/mL; equivalent to 50 to 125 nmol/L). Blood levels necessary to cause adverse effects in adults are thought to be greater than about 150 ng/mL. [4]: 424–446
Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
While men are less likely to develop osteoporosis, it is possible and has been occurring more often in recent years in men over age 65. “Most men should aim for 1,000 - 1,200mg of calcium per ...
Now, new research finds that women who use hormone therapy after age 65 are usually fine to do just that — but the dose and timing of the treatment matter. The study, which was published in ...
The recommended daily amount of drinking water for humans varies. [1] It depends on activity, age, health, and environment.In the United States, the Adequate Intake for total water, based on median intakes, is 4.0 litres (141 imp fl oz; 135 US fl oz) per day for males older than 18, and 3.0 litres (106 imp fl oz; 101 US fl oz) per day for females over 18; it assumes about 80% from drink and 20 ...
The CDC’s new COVID-19 vaccine recommendations suggest a second dose of the updated COVID-19 vaccine for people who are 65+, as well as those who are moderately or severely immunocompromised ...
Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D 3 (abbreviated 25(OH)D 3), [1] is a form of vitamin D produced in the liver by hydroxylation of vitamin D 3 (cholecalciferol) by the enzyme vitamin D 25-hydroxylase.