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Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), [3] is a group of respiratory diseases affecting the interstitium (the tissue) and space around the alveoli (air sacs) of the lungs. [4] It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. It ...
It is a type of interstitial lung disease. [3] People often benefit from pulmonary rehabilitation and supplemental oxygen. [1] Certain medications like pirfenidone or nintedanib may slow the progression of the disease. [2] Lung transplantation may also be an option. [1] About 5 million people are affected globally. [8]
Usual interstitial pneumonia (UIP) is a form of lung disease characterized by progressive scarring of both lungs. [1] The scarring (pulmonary fibrosis) involves the pulmonary interstitium (the supporting framework of the lung). UIP is thus classified as a form of interstitial lung disease.
It is still unknown what causes interstitial lung disease associated with antisynthetase syndrome. [5] Many antisynthetase antibodies have been reported with anti-Jo1 being the most prevalent. [ 6 ] Pulmonary involvement is an important factor of morbidity and mortality with Antisynthetase syndrome, affecting 70–100% of patients.
Pulmonary hypertension, respiratory failure, pneumothorax, lung cancer [2] Causes: Tobacco smoking, environmental pollution, certain medications, connective tissue diseases, interstitial lung disease, unknown [1] [3] Treatment: Oxygen therapy, pulmonary rehabilitation, lung transplantation [4] Medication: Pirfenidone, nintedanib [4] Prognosis ...
While a lung biopsy is the gold standard, some clinicians opt against this due to the risks of the procedure. Lung biopsies performed on patients with NSIP reveal two different disease patterns – cellular and fibrosing – which are associated with different prognoses. The cellular pattern displays chronic inflammation with minimal fibrosis.
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