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MALDI mass spectrometry imaging (MALDI-MSI) is the use of matrix-assisted laser desorption ionization as a mass spectrometry imaging [2] technique in which the sample, often a thin tissue section, is moved in two dimensions while the mass spectrum is recorded. [3]
More than 50 years ago, MSI was introduced using secondary ion mass spectrometry (SIMS) to study semiconductor surfaces by Castaing and Slodzian. [5] However, it was the pioneering work of Richard Caprioli and colleagues in the late 1990s, demonstrating how matrix-assisted laser desorption/ionization (MALDI) could be applied to visualize large biomolecules (as proteins and lipids) in cells and ...
The IR-MALDESI MSI source was designed and implemented in 2013, [3] and is coupled to a high resolving power hybrid Quadrupole-Orbitrap mass spectrometer. The computer controlled motorized stage and a charge-coupled device (CCD) camera are placed in a nitrogen purged enclosure where ambient ions and relative humidity can be regulated.
Peptide mass fingerprinting is the most popular analytical application of MALDI-TOF mass spectrometers. MALDI TOF/TOF mass spectrometers are used to reveal amino acid sequence of peptides using post-source decay or high energy collision-induced dissociation (further use see mass spectrometry). MALDI-TOF have been used to characterise post ...
Software for mass spectrometry imaging developed by the Swiss Institute of Bioinformatics. [67] MSiReader Freeware: Vendor-neutral interface built on the Matlab platform designed to view and perform data analysis of mass spectrometry imaging (MSI) data. [68] Matlab is not required to use MSiReader. MS Interpreter Freeware
Laser ablation electrospray ionization (LAESI) mass spectrometry is an ambient ionization technique applicable to plant and animal tissue imaging, live-cell imaging, and most recently to cell-by-cell imaging. [14] This technique uses a mid-IR laser to ablate the sample which creates a cloud of neutral molecules.
Tulsi Gabbard, President Donald Trump’s nominee to be Director of National Intelligence, testifies at her confirmation hearing before the Senate Intelligence Committee in Washington, DC, on ...
In mass spectrometry, a matrix is a compound that promotes the formation of ions. Matrix compounds are used in matrix-assisted laser desorption/ionization (MALDI), matrix-assisted ionization (MAI), and fast atom bombardment (FAB).