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Cytokine-induced killer cells (CIK) cells are a group of immune effector cells featuring a mixed T- and natural killer (NK) cell-like phenotype.They are generated by ex vivo incubation of human peripheral blood mononuclear cells (PBMC) or cord blood mononuclear cells with interferon-gamma (), anti-CD3 antibody, recombinant human interleukin (IL)-1 and recombinant human interleukin (IL)-2.
Receptors for myokines are found on muscle, fat, liver, pancreas, bone, heart, immune, and brain cells. [2] The location of these receptors reflects the fact that myokines have multiple functions. Foremost, they are involved in exercise-associated metabolic changes, as well as in the metabolic changes following training adaptation. [ 1 ]
On the other hand, the action of IL-23 or IL-17 is not always beneficial. It causes some autoimmune diseases such as multiple sclerosis [16] or rheumatoid arthritis. [17] IL-17A specifically targets keratinocytes and is the major cytokine causing pathogenesis of skin psoriasis. [18]
In cell biology, a lymphokine-activated killer cell (also known as a LAK cell) is a white blood cell, consisting mostly of natural killer, natural killer T, and T cells that has been stimulated to kill tumor cells, but because of the function in which they activate, and the cells they can successfully target, they are classified as different than the classical natural killer and T lymphocyte ...
The muscle, gland or organ cell capable of responding to a stimulus at the terminal end of an efferent nerve fiber; Plasma cell, an effector B cell in the immune system; Effector T cells, T cells that actively respond to a stimulus; Cytokine-induced killer cells, strongly productive cytotoxic effector cells that are capable of lysing tumor ...
It refers to cytokine storm syndromes (CSS) [4] and occurs when large numbers of white blood cells are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. CRS is also an adverse effect of some monoclonal antibody medications, as well as adoptive T-cell therapies .
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene.IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain and the common gamma chain (gamma-C, CD132).
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. [ 5 ] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. [ 6 ]